CLS CLS Hematology and Coagulation 2

Question 1

Which stain is routinely used to identify malaria parasites on a peripheral blood smear?

Accepted Answer

Wright-Giemsa stain

Answer

Wright-Giemsa stain is the standard stain for peripheral blood smear examination, including identification of intraerythrocytic malaria parasites.

Question 2

Sickle cell disease results from a mutation in which protein?

Accepted Answer

Hemoglobin

Answer

Sickle cell disease is caused by a point mutation (Glu→Val) in the beta-globin gene, producing abnormal hemoglobin S.

Question 3

The aPTT (activated Partial Thromboplastin Time) is primarily used to assess which pathway and monitor which therapy?

Accepted Answer

Intrinsic and common pathways; heparin monitoring

Answer

aPTT evaluates the intrinsic and common coagulation pathways and is the primary test used to monitor unfractionated heparin therapy.

Question 4

Hemolytic Uremic Syndrome (HUS) is classically characterized by which triad?

Accepted Answer

Microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure

Answer

HUS presents with the classic triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure, often following E. coli O157:H7 infection.

Question 5

In a complete blood count, what does a high RDW (Red Cell Distribution Width) indicate?

Accepted Answer

Greater variation in red cell size (anisocytosis)

Answer

RDW quantifies variation in red blood cell size (anisocytosis); an elevated RDW indicates a heterogeneous population of red cells.

CLS - Certified Laboratory Professional Practice Test

CLS - Certified Laboratory Professional Practice Test

CLS CLS Hematology and Coagulation 2