CLS Hematology and Coagulation Flashcards
6 cards from real CLS practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 CLS Hematology and Coagulation flashcards as text
Which type of anemia presents with macrocytic red cells and hypersegmented neutrophils (≥5 lobes) on peripheral smear?
Answer: Megaloblastic anemia
Megaloblastic anemia, caused by vitamin B12 or folate deficiency, produces macrocytic red cells and hypersegmented neutrophils due to impaired DNA synthesis.
What is the primary function of thrombopoietin in hematopoiesis?
Answer: Stimulate megakaryocyte differentiation and platelet production
Thrombopoietin, produced mainly by the liver, stimulates megakaryocyte maturation and platelet production in the bone marrow.
Which laboratory test definitively differentiates Hemophilia A (Factor VIII deficiency) from Hemophilia B (Factor IX deficiency)?
Answer: Specific factor activity assay
Specific factor activity assays identify whether Factor VIII or Factor IX is deficient, since both conditions prolong the aPTT similarly.
Target cells (codocytes) on a peripheral smear are most associated with which conditions?
Answer: Iron deficiency anemia, liver disease, and hemoglobin C disease
Target cells result from an increased surface-to-volume ratio and are characteristically seen in iron deficiency anemia, liver disease, thalassemia, and hemoglobin C disease.
A positive Direct Antiglobulin Test (DAT) indicates what finding?
Answer: Antibodies or complement bound to red blood cells in vivo
A positive DAT (direct Coombs test) demonstrates that IgG antibodies or complement components are coating the patient's red blood cells in vivo.
How do modern automated hematology analyzers calculate the hematocrit?
Answer: RBC count × MCV / 10
Calculated hematocrit = RBC count (×10⁶/µL) × MCV (fL) / 10, representing the percentage of blood volume occupied by red cells.