CHS Pharmacology & Medication Management 3

Question 1

Doxorubicin (Adriamycin) is considered a relative contraindication for HBO therapy because it:

Accepted Answer

Potentiates cardiotoxicity under high oxygen partial pressures

Answer

Doxorubicin has known cardiotoxic effects, and high oxygen partial pressures may potentiate cardiac oxidative damage in patients receiving this agent.

Question 2

When managing a patient on warfarin undergoing HBO therapy for chronic wound care, the clinician should be aware that HBO may:

Accepted Answer

Potentiate anticoagulant effects by increasing platelet sensitivity

Answer

HBO therapy has been shown to potentiate the anticoagulant effects of warfarin, requiring closer INR monitoring in patients on long-term HBO courses.

Question 3

Which medication used for carbon monoxide poisoning acts synergistically with HBO by increasing CO elimination from cytochrome oxidase?

Accepted Answer

Hydroxocobalamin

Answer

Hydroxocobalamin binds cyanide and works alongside HBO in combined CO/cyanide poisoning (as in smoke inhalation), while HBO displaces CO from hemoglobin and cytochrome oxidase.

Question 4

Nitroglycerin patches worn by a patient during HBO should be managed how?

Accepted Answer

Removed before treatment to prevent unpredictable absorption and fire risk

Answer

Nitroglycerin patches should be removed before HBO sessions because pressure alters transdermal absorption rates and the adhesive base may pose a fire hazard.

Question 5

A hyperbaric patient on theophylline (bronchodilator) requires careful monitoring because HBO may:

Accepted Answer

Lower the seizure threshold in combination with theophylline's CNS effects

Answer

Theophylline lowers the seizure threshold via adenosine antagonism, and this effect is additive with CNS oxygen toxicity risk in HBO therapy.

(CHS) Certified Hypertension Specialist Practice Test

(CHS) Certified Hypertension Specialist Practice Test

CHS Pharmacology & Medication Management 3