CHS CHS Research & Evidence-Based Practice 1

Question 1

Which landmark clinical trial demonstrated that intensive systolic blood pressure treatment to a target below 120 mmHg reduced cardiovascular events compared to a target of 140 mmHg?

Accepted Answer

SPRINT trial

Answer

The SPRINT (Systolic Blood Pressure Intervention Trial) trial showed that targeting systolic BP below 120 mmHg significantly reduced cardiovascular events and all-cause mortality.

Question 2

In evidence-based practice, what does the term 'NNT' (Number Needed to Treat) represent?

Accepted Answer

The number of patients who must be treated to prevent one adverse event

Answer

NNT is the number of patients who need to receive a treatment for a given duration to prevent one additional adverse outcome compared to control.

Question 3

The ALLHAT trial, the largest hypertension outcomes trial in US history, demonstrated that which antihypertensive class was equally or more effective than newer agents for preventing major CV outcomes?

Accepted Answer

Thiazide diuretics

Answer

ALLHAT showed that chlorthalidone (a thiazide-type diuretic) was equivalent or superior to newer agents for preventing major cardiovascular outcomes, cementing its first-line status.

Question 4

Which study design provides the highest level of evidence for evaluating the effectiveness of antihypertensive treatments?

Accepted Answer

Randomized controlled trial (RCT)

Answer

Randomized controlled trials provide the highest level of evidence for causality and treatment effectiveness because randomization minimizes confounding bias.

Question 5

What is the primary purpose of a meta-analysis in hypertension research?

Accepted Answer

To pool results from multiple studies to increase statistical power and precision

Answer

A meta-analysis statistically combines data from multiple independent studies to generate more precise estimates of treatment effects than any individual study can provide.

(CHS) Certified Hypertension Specialist Practice Test

(CHS) Certified Hypertension Specialist Practice Test

CHS CHS Research & Evidence-Based Practice 1