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Pharmacology and Sedation Flashcards

6 cards from real CGRN practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

Read the first 6 Pharmacology and Sedation flashcards as text

  1. What is the mechanism of action of propofol used for endoscopic sedation?

    Answer: GABA-A receptor potentiation

    Propofol potentiates GABA-A receptor activity, producing rapid-onset sedation with very short duration.

  2. A patient receiving fentanyl and midazolam becomes unresponsive. Which medication should be given first?

    Answer: Naloxone 0.04-0.1 mg IV titrated

    Start with low-dose naloxone (0.04-0.1 mg) titrated to reverse respiratory depression while minimizing pain reversal.

  3. Which PPI has the strongest CYP2C19 inhibition and highest drug interaction potential?

    Answer: Omeprazole

    Omeprazole has the strongest CYP2C19 inhibitory effect, particularly affecting clopidogrel.

  4. What is the primary advantage of CO2 insufflation over room air during endoscopy?

    Answer: CO2 is absorbed 150 times faster than nitrogen, reducing post-procedure bloating

    CO2 is absorbed 150 times faster than nitrogen, dramatically reducing post-procedure distention and pain.

  5. What antibiotic prophylaxis is recommended before endoscopy in a patient with a prosthetic heart valve?

    Answer: No antibiotic prophylaxis is recommended

    Current guidelines do NOT recommend routine antibiotic prophylaxis for GI endoscopy solely for cardiac conditions.

  6. What is the onset time and peak effect of IV midazolam for endoscopic sedation?

    Answer: Onset 1-2 minutes, peak 3-5 minutes

    IV midazolam has onset of 1-2 minutes with peak at 3-5 minutes.

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