CHT Hyperbaric Pharmacology Flashcards
6 cards from real Certified Hyperbaric Technologist Test practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 CHT Hyperbaric Pharmacology flashcards as text
How does hyperbaric oxygen therapy enhance the action of antibiotics such as aminoglycosides?
Answer: HBO increases oxygen tension in tissue, restoring the oxygen-dependent transport needed for antibiotic uptake
Aminoglycosides require oxygen-dependent active transport into bacteria; HBO restores this mechanism in hypoxic infected tissue.
Bleomycin chemotherapy is considered a relative contraindication for HBO because it:
Answer: Sensitizes the lungs to oxygen toxicity
Bleomycin causes pulmonary fibrosis, and HBO can exacerbate this by increasing oxidative stress in already damaged lung tissue.
Why should insulin-dependent diabetics have their insulin dosing evaluated before a course of HBO treatments?
Answer: HBO enhances glucose uptake and insulin sensitivity, potentially causing hypoglycemia
HBO increases insulin sensitivity and promotes cellular glucose uptake, which can lower blood glucose significantly in diabetic patients.
Cisplatin (a chemotherapy drug) combined with HBO is concerning because:
Answer: It increases the risk of both renal toxicity and ototoxicity under hyperoxic conditions
Cisplatin's nephrotoxic and ototoxic effects can be exacerbated by the oxidative stress associated with HBO therapy.
Which statement about HBO and anticoagulants (e.g., warfarin) is correct?
Answer: HBO may enhance anticoagulant effects, requiring INR monitoring
HBO can affect platelet function and coagulation pathways, necessitating careful INR monitoring in patients on anticoagulants.
Which class of drugs lowers the CNS oxygen toxicity threshold when combined with HBO?
Answer: Tricyclic antidepressants
Tricyclic antidepressants lower the seizure threshold and can increase the likelihood of CNS oxygen toxicity during HBO therapy.
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