CHT Hyperbaric Pharmacology Flashcards
6 cards from real Certified Hyperbaric Technologist Test practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.
Read the first 6 CHT Hyperbaric Pharmacology flashcards as text
When a patient is receiving HBO for a gas-forming infection, which antibiotic class works synergistically with HBO against Clostridium species?
Answer: Penicillins (e.g., ampicillin)
Penicillins are the cornerstone antibiotic against Clostridium; HBO synergizes by creating a high-oxygen environment directly hostile to these anaerobes.
A patient on metronidazole (Flagyl) is receiving HBO for necrotizing fasciitis. A key consideration is:
Answer: Metronidazole requires oxygen reduction to form toxic radicals, so HBO may reduce its effectiveness against anaerobes
Metronidazole requires low-oxygen conditions for its activation mechanism; HBO may reduce anaerobic activation while still providing direct bactericidal oxygen effects.
HBO's vasoconstriction effect is clinically useful in which situation?
Answer: Reducing edema in crush injuries and compartment syndrome
HBO-induced vasoconstriction reduces edema and swelling in crush injuries while still delivering adequate oxygen via dissolved plasma O2.
Sildenafil (Viagra) and HBO are potentially problematic together because:
Answer: Both cause vasodilation and may produce significant hypotension
Both sildenafil (PDE5 inhibitor) and HBO independently cause vasodilation; combined use may result in significant hypotension.
In radiation-injured tissue, HBO promotes healing by:
Answer: Stimulating stem cell mobilization and angiogenesis in hypoxic tissue
HBO mobilizes CD34+ stem cells from bone marrow and stimulates VEGF-driven angiogenesis in the hypoxic, avascular post-radiation tissue.
What is the rationale for using HBO in cyanide poisoning?
Answer: HBO provides dissolved plasma oxygen that bypasses cytochrome oxidase inhibition by cyanide
Since cyanide blocks cytochrome oxidase, dissolved plasma oxygen from HBO can supply tissue needs without passing through the blocked mitochondrial chain.
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