Medications and Pharmacology in Dialysis Flashcards
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Which medication is used to reverse heparin anticoagulation in cases of bleeding during hemodialysis?
Answer: Protamine sulfate
Protamine sulfate binds and neutralizes heparin, rapidly reversing its anticoagulant effect.
Cinacalcet (Sensipar) is used in dialysis patients to treat which condition?
Answer: Secondary hyperparathyroidism
Cinacalcet is a calcimimetic that sensitizes the calcium-sensing receptor on parathyroid cells, suppressing PTH secretion in secondary hyperparathyroidism.
Which active form of vitamin D is most commonly prescribed to dialysis patients?
Answer: Calcitriol (1,25-dihydroxyvitamin D)
Calcitriol is the active form of vitamin D prescribed to dialysis patients because failed kidneys cannot perform the final hydroxylation step.
What is the primary concern when administering EPO (erythropoietin) to a dialysis patient with uncontrolled hypertension?
Answer: EPO can further increase blood pressure and risk of stroke
ESA therapy can raise blood pressure and increase stroke risk, requiring blood pressure control before and during ESA administration.
A dialysis patient taking calcium carbonate as a phosphate binder should be instructed to take it:
Answer: With meals to bind dietary phosphate
Calcium carbonate must be taken with meals to bind phosphate from food in the GI tract before it can be absorbed.
Which electrolyte imbalance is most commonly treated with sodium bicarbonate supplementation in dialysis patients?
Answer: Metabolic acidosis
Dialysis patients frequently develop metabolic acidosis due to inability to excrete acid, treated with bicarbonate in dialysate or oral supplementation.