CDN Nutritional Genomics & Precision 3

Question 1

A client carries the BCMO1 R267S polymorphism affecting beta-carotene conversion. The most appropriate precision nutrition recommendation is:

Accepted Answer

Supplement with pre-formed retinol (vitamin A)

Answer

BCMO1 R267S reduces beta-carotene to retinol conversion efficiency, so individuals may need pre-formed vitamin A rather than relying solely on provitamin A carotenoids.

Question 2

The lactase persistence allele (LCT -13910 C>T) enables continued lactase expression in adults due to its effect on:

Accepted Answer

An enhancer element regulating LCT transcription

Answer

The C>T variant at position -13910 upstream of LCT creates a binding site for transcription factors that enhance lactase expression into adulthood.

Question 3

Which omics technology directly measures the complete set of proteins expressed by a cell or tissue?

Accepted Answer

Proteomics

Answer

Proteomics characterizes the full complement of proteins expressed at a given time, capturing post-translational modifications that genomics and transcriptomics cannot detect.

Question 4

A variant in the FADS1 gene affects which dietary fatty acid conversion pathway?

Accepted Answer

Conversion of ALA to EPA and DHA

Answer

FADS1 encodes delta-5 desaturase, which is critical for converting ALA to longer-chain omega-3 fatty acids EPA and DHA.

Question 5

In precision nutrition, the primary clinical utility of measuring a client's metabolome is to:

Accepted Answer

Identify real-time metabolic phenotype and nutrient status

Answer

Metabolomics captures the downstream functional output of genome-environment interactions, reflecting actual metabolic state and nutritional biomarker levels.

(CDN) Certified Dietician Nutritionist Practice Test

(CDN) Certified Dietician Nutritionist Practice Test

CDN Nutritional Genomics & Precision 3