CDN Nutritional Genomics & Precision 2

Question 1

Which single nucleotide polymorphism (SNP) in the MTHFR gene is most commonly associated with reduced folate metabolism?

Accepted Answer

C677T

Answer

The MTHFR C677T polymorphism reduces enzyme activity by up to 70% in homozygotes, impairing folate conversion to its active form.

Question 2

Nutrigenomics differs from nutrigenetics primarily in that nutrigenomics focuses on:

Accepted Answer

How nutrients alter gene expression patterns

Answer

Nutrigenomics studies how dietary components influence gene expression, while nutrigenetics examines how genetic variation shapes individual responses to nutrients.

Question 3

A patient with the APOE ε4 allele would most benefit from which dietary intervention based on genetic evidence?

Accepted Answer

Reduced saturated fat intake

Answer

APOE ε4 carriers show greater LDL cholesterol elevations in response to saturated fat compared to APOE ε3 carriers.

Question 4

Which term describes the study of heritable changes in gene expression that do not involve alterations to the DNA sequence?

Accepted Answer

Epigenomics

Answer

Epigenomics examines modifications such as DNA methylation and histone acetylation that regulate gene expression without changing nucleotide sequences.

Question 5

The FTO gene rs9939609 variant is most strongly associated with increased risk of:

Accepted Answer

Obesity and elevated BMI

Answer

The FTO rs9939609 A allele is one of the most replicated genetic variants associated with higher BMI and obesity susceptibility.

(CDN) Certified Dietician Nutritionist Practice Test

(CDN) Certified Dietician Nutritionist Practice Test

CDN Nutritional Genomics & Precision 2