CCP CCP Blood Conservation & Transfusion Strategies 3

Question 1

Fresh frozen plasma (FFP) is indicated post-CPB when:

Accepted Answer

PT/INR is significantly elevated with active microvascular bleeding

Answer

FFP contains all clotting factors and is indicated for coagulopathic bleeding with elevated PT/INR, not as a volume expander.

Question 2

Cryoprecipitate is administered post-bypass primarily to replace:

Accepted Answer

Fibrinogen and factor VIII

Answer

Cryoprecipitate is enriched with fibrinogen, factor VIII, vWF, and factor XIII, making it the preferred product for fibrinogen replacement in coagulopathic bleeding.

Question 3

Preoperative autologous donation (PAD) for elective cardiac surgery is currently:

Accepted Answer

Largely abandoned due to evidence of preoperative anemia induction with no clear benefit

Answer

PAD is no longer routinely recommended because donating blood preoperatively induces anemia that may offset any transfusion benefit, and trials have not shown improved outcomes.

Question 4

Acute normovolemic hemodilution (ANH) works by:

Accepted Answer

Collecting whole blood at surgery start, replacing volume with crystalloid/colloid, then retransfusing after bypass

Answer

ANH collects whole blood before bypass and stores it at bedside under normothermic conditions; this fresh autologous blood, rich in clotting factors and platelets, is retransfused after bypass.

Question 5

Point-of-care platelet function testing using devices such as the Multiplate analyzer helps guide:

Accepted Answer

Targeted platelet transfusion decisions in coagulopathic patients

Answer

Platelet function analyzers assess aggregation defects, helping clinicians determine whether platelet transfusion will address the source of bleeding versus other factor deficiencies.

(CCP) Certified Clinical Perfusionist Practice Test

(CCP) Certified Clinical Perfusionist Practice Test

CCP CCP Blood Conservation & Transfusion Strategies 3