A patient with opioid use disorder on methadone maintenance is prescribed rifampin for tuberculosis. What pharmacokinetic interaction should the nurse anticipate?
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A
Rifampin inhibits CYP3A4, increasing methadone levels and risk of overdose
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B
Rifampin induces CYP3A4, reducing methadone levels and potentially precipitating withdrawal
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C
Rifampin displaces methadone from protein-binding sites
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D
Rifampin enhances renal excretion of methadone