Which pharmacokinetic property of fentanyl makes transdermal patches particularly dangerous when misused (e.g., chewed or injected with extracted gel)?
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A
Fentanyl has low protein binding allowing rapid systemic distribution
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B
Fentanyl patches contain a reservoir of drug designed for 72-hour release that can be rapidly absorbed if misused
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C
Fentanyl undergoes extensive first-pass metabolism when swallowed
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D
Fentanyl has a very long half-life of 48 hours