Which mechanism of action explains why beta-blockers reduce mortality in heart failure with reduced ejection fraction?
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A
Blocking catecholamine overstimulation reduces cardiac remodeling, improves ejection fraction, and prevents arrhythmic death
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B
Beta-blockers primarily reduce preload by blocking aldosterone receptors
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C
Beta-blockers increase cardiac output acutely by improving contractility
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D
Beta-blockers prevent heart failure by directly inhibiting RAAS activation