CAOP Sterile Products and Aseptic Technique 2

Question 1

Which type of biological safety cabinet (BSC) is used when preparing hazardous drugs?

Accepted Answer

Class II Type B2 BSC

Answer

A Class II Type B2 BSC is total-exhaust and externally vented, providing both product and personnel protection required for hazardous drug compounding.

Question 2

What is the significance of endotoxin testing (LAL test) for parenteral products?

Accepted Answer

It detects bacterial endotoxins (pyrogens) that can cause fever and septic shock

Answer

The Limulus Amebocyte Lysate (LAL) test detects gram-negative bacterial endotoxins that can cause pyrogenic reactions even if the product is sterile.

Question 3

Which hand hygiene step is CRITICAL before gowning for sterile compounding?

Accepted Answer

Performing a surgical hand scrub with an antimicrobial agent for at least 30 seconds

Answer

A thorough antiseptic hand scrub removes transient microorganisms and reduces resident flora before donning sterile gloves for aseptic compounding.

Question 4

A pharmacist notices visible particles in a prepared IV bag. The CORRECT action is to:

Accepted Answer

Quarantine and discard the preparation, then investigate the cause

Answer

Visible particulate matter indicates contamination or incompatibility; the preparation must be discarded and the root cause investigated to prevent patient harm.

Question 5

What is the function of a 0.22-micron filter used in IV admixture preparation?

Accepted Answer

Sterilizes the solution by removing bacteria and particulates ≥0.22 µm

Answer

A 0.22-micron sterilizing filter removes bacteria, fungi, and particulate matter, providing terminal sterilization for preparations that cannot be autoclaved.

CAOP - Competency Assessment of Overseas Pharmacist Practice Test

CAOP - Competency Assessment of Overseas Pharmacist Practice Test

CAOP Sterile Products and Aseptic Technique 2