A 45-year-old man asks for an over-the-counter proton pump inhibitor for heartburn. Which finding most clearly requires referral to a doctor instead of self-treatment?
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A
Heartburn that occurs mainly after large, fatty meals
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B
Difficulty swallowing and unintentional weight loss over the past two months
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C
Symptoms about twice a week for the past month
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D
Symptoms that go away within minutes after taking an antacid