Board Certified Ophthalmologist Glaucoma Diagnosis and Management 3

Question 1

Latanoprost lowers IOP primarily by:

Accepted Answer

Increasing uveoscleral outflow

Answer

Prostaglandin F2α analogs remodel ciliary muscle extracellular matrix to increase uveoscleral outflow.

Question 2

Which adverse effect is particularly characteristic of netarsudil?

Accepted Answer

Cornea verticillata

Answer

The Rho kinase inhibitor netarsudil commonly causes hyperemia and whorl-like corneal deposits (verticillata).

Question 3

Brimonidine should be avoided in infants and young children chiefly because of:

Accepted Answer

CNS depression and apnea

Answer

Brimonidine crosses the immature blood-brain barrier and can cause somnolence, hypotension, and apnea in infants.

Question 4

Which glaucoma medication is contraindicated in a patient with moderate persistent asthma?

Accepted Answer

Timolol

Answer

Nonselective beta-blockers like timolol can precipitate bronchospasm.

Question 5

A patient on oral acetazolamide is most likely to develop which laboratory abnormality?

Accepted Answer

Hypokalemia with metabolic acidosis

Answer

Systemic carbonic anhydrase inhibitors cause bicarbonate wasting and potassium loss, leading to hypokalemic metabolic acidosis.

Board Certified Ophthalmologist Practice Test