Biochemistry Carbohydrate Chemistry and Metabolism 2

Question 1

Phosphofructokinase-1 (PFK-1) is the key regulatory enzyme of glycolysis. Which molecule allosterically activates it?

Accepted Answer

AMP

Answer

ATP

Answer

Citrate

Answer

Acetyl-CoA

Question 2

Pyruvate dehydrogenase complex (PDC) converts pyruvate to acetyl-CoA with release of:

Accepted Answer

CO₂ and NADH

Answer

CO₂ and FADH₂

Answer

H₂O and NADPH

Answer

CO₂ and ATP

Question 3

Under anaerobic conditions in muscle, pyruvate is converted to lactate to regenerate:

Accepted Answer

NAD⁺

Answer

ATP

Answer

FADH₂

Answer

Acetyl-CoA

Question 4

The pentose phosphate pathway (PPP) primarily generates which two products needed for biosynthesis?

Accepted Answer

NADPH and ribose-5-phosphate

Answer

ATP and NADH

Answer

Acetyl-CoA and oxaloacetate

Answer

Pyruvate and lactate

Question 5

Gluconeogenesis is the synthesis of glucose from non-carbohydrate precursors. Which of the following is NOT a gluconeogenic precursor?

Accepted Answer

Acetyl-CoA

Answer

Lactate

Answer

Glycerol

Answer

Oxaloacetate

Question 6

Von Gierke disease (Type I glycogen storage disease) is caused by deficiency of:

Accepted Answer

Glucose-6-phosphatase

Answer

Glycogen phosphorylase

Answer

Debranching enzyme

Answer

Glycogen synthase