BCACP Clinical Literature Interpretation 3

Question 1

A cohort study follows patients with and without statin use over 10 years to assess cardiovascular events. What measure of association is most appropriate to report?

Accepted Answer

Relative risk (RR)

Answer

Relative risk is the preferred measure of association in cohort studies with known incidence rates.

Question 2

A study has a wide 95% confidence interval crossing 1.0 for an odds ratio. What does this indicate?

Accepted Answer

The result is not statistically significant

Answer

A 95% CI for an odds ratio that includes 1.0 indicates no statistically significant difference between groups.

Question 3

Which study design provides the highest level of evidence for evaluating therapeutic interventions?

Accepted Answer

Systematic review with meta-analysis of randomized controlled trials

Answer

Systematic reviews with meta-analyses of RCTs sit at the top of the evidence hierarchy for therapeutic questions.

Question 4

In a crossover trial, which design feature helps control for carryover effects?

Accepted Answer

Washout period between treatment phases

Answer

A washout period allows prior treatment effects to dissipate before the next phase begins, controlling for carryover.

Question 5

A pharmacist reviews a trial where the primary endpoint was changed after enrollment began but before unblinding. This is an example of:

Accepted Answer

Outcome reporting bias

Answer

Changing the primary endpoint after trial initiation but before unblinding introduces outcome reporting bias.

BCACP - Board Certified Ambulatory Care Pharmacist Exam Practice Test

BCACP - Board Certified Ambulatory Care Pharmacist Exam Practice Test

BCACP Clinical Literature Interpretation 3