B.Pharm. Bachelor of Pharmacy Biopharmaceutics & Pharmacokinetics 1

Question 1

Bioavailability is defined as the fraction of an administered dose of drug that reaches the:

Accepted Answer

Systemic circulation in active form

Answer

Bioavailability (F) measures the fraction of an administered dose that reaches the systemic circulation in unchanged, active form and is available to exert pharmacological effects.

Question 2

Which pharmacokinetic parameter describes the volume of plasma completely cleared of a drug per unit time?

Accepted Answer

Clearance

Answer

Clearance (Cl) is the pharmacokinetic parameter defined as the volume of plasma completely cleared of a drug per unit time, typically expressed in mL/min or L/hr.

Question 3

The first-pass effect refers to the metabolism of a drug that occurs:

Accepted Answer

In the gut wall and liver before reaching systemic circulation

Answer

The first-pass effect (presystemic metabolism) occurs in the gut wall and liver, where orally administered drugs are extensively metabolized before reaching the systemic circulation, reducing bioavailability.

Question 4

Which route of administration completely bypasses the first-pass effect?

Accepted Answer

Intravenous

Answer

Intravenous (IV) administration delivers the drug directly into the systemic circulation, completely bypassing the liver and gut wall, thus avoiding the first-pass effect entirely.

Question 5

The biological half-life of a drug is the time required for the plasma drug concentration to:

Accepted Answer

Decrease by 50%

Answer

The half-life (t½) is the time required for the plasma drug concentration to decrease by exactly 50%, and it governs the dosing frequency and time to reach steady-state.

B.Pharm. Bachelor of Pharmacy Practice Test

B.Pharm. Bachelor of Pharmacy Practice Test

B.Pharm. Bachelor of Pharmacy Biopharmaceutics & Pharmacokinetics 1