B.Pharm. Bachelor of Pharmacy Biopharmaceutics & Pharmacokinetics

Question 1

Bioavailability is defined as the fraction of an administered dose of drug that reaches the:

Accepted Answer

Systemic circulation in active form

Answer

Gastrointestinal tract unchanged

Answer

Liver before metabolism

Answer

Target receptor site

Question 2

Which pharmacokinetic parameter describes the volume of plasma completely cleared of a drug per unit time?

Accepted Answer

Clearance

Answer

Volume of distribution

Answer

Half-life

Answer

Bioavailability

Question 3

The first-pass effect refers to the metabolism of a drug that occurs:

Accepted Answer

In the gut wall and liver before reaching systemic circulation

Answer

In the kidneys before excretion

Answer

In the plasma after absorption

Answer

At the site of drug administration

Question 4

Which route of administration completely bypasses the first-pass effect?

Accepted Answer

Intravenous

Answer

Oral

Answer

Rectal

Answer

Sublingual

Question 5

The biological half-life of a drug is the time required for the plasma drug concentration to:

Accepted Answer

Decrease by 50%

Answer

Reach its maximum value

Answer

Reach steady-state

Answer

Fall to zero

Question 6

The one-compartment open model assumes that the drug:

Accepted Answer

Behaves as if the entire body is a single homogeneous unit

Answer

Distributes unequally between tissues

Answer

Is eliminated only by renal excretion

Answer

Has non-linear pharmacokinetics

Question 7

In pharmacokinetic studies, Cmax refers to the:

Accepted Answer

Maximum plasma drug concentration achieved after a single dose

Answer

Minimum effective plasma drug concentration

Answer

Plasma concentration at steady state

Answer

Concentration causing 50% of maximum effect