B.Pharm. Bachelor of Pharmacy Bachelor of Pharmacy (B.Pharm.) Pharmaceutics 5

Question 1

Which excipient is used as a cryoprotectant in lyophilized protein formulations to prevent aggregation during freezing?

Accepted Answer

Sucrose

Answer

Sucrose and trehalose stabilize proteins during freeze-drying by replacing hydrogen bonds lost when water is removed.

Question 2

The HLB (Hydrophilic-Lipophilic Balance) value range of 8–18 is preferred for surfactants used as:

Accepted Answer

O/W emulsifiers

Answer

High HLB values (8–18) indicate predominantly hydrophilic character, favoring formation of O/W emulsions.

Question 3

Transdermal drug delivery systems are most suitable for drugs with molecular weight less than:

Accepted Answer

500 Da

Answer

Skin permeation is generally limited to molecules below ~500 Da; larger molecules cannot efficiently cross the stratum corneum.

Question 4

Zero-order drug release from a dosage form means the drug is released at:

Accepted Answer

A constant rate independent of drug concentration

Answer

Zero-order release delivers a constant amount of drug per unit time, providing stable plasma concentrations.

Question 5

A pharmaceutical suspension that settles slowly and can be easily redispersed with gentle shaking is called a:

Accepted Answer

Flocculated suspension

Answer

Flocculated suspensions form loose aggregates (flocs) that sediment as a fluffy cake and redisperse easily.

B.Pharm. Bachelor of Pharmacy Practice Test