B.Pharm. Bachelor of Pharmacy Bachelor of Pharmacy (B.Pharm.) Pharmaceutics 4

Question 1

The Biopharmaceutics Classification System (BCS) Class II drugs have:

Accepted Answer

Low solubility and high permeability

Answer

BCS Class II drugs are poorly soluble but highly permeable; dissolution is the rate-limiting step for absorption.

Question 2

Which sterilization method is most appropriate for thermolabile ophthalmic solutions?

Accepted Answer

Filtration through a 0.22 µm membrane

Answer

Membrane filtration (0.22 µm) removes microorganisms without heat, preserving thermolabile drug integrity.

Question 3

In a two-compartment pharmacokinetic model, the initial rapid decline in plasma drug concentration after IV bolus represents:

Accepted Answer

Distribution of drug from central to peripheral compartment

Answer

The alpha (distribution) phase reflects rapid drug transfer from plasma into peripheral tissues following IV injection.

Question 4

Crospovidone (cross-linked PVP) is classified as a:

Accepted Answer

Superdisintegrant

Answer

Crospovidone rapidly wicks water and swells, functioning as a superdisintegrant to facilitate tablet breakup.

Question 5

The critical micellar concentration (CMC) is the surfactant concentration above which:

Accepted Answer

Micelles spontaneously form in solution

Answer

Above the CMC, surfactant monomers aggregate into micelles, dramatically improving solubilization of lipophilic drugs.

B.Pharm. Bachelor of Pharmacy Practice Test