B.Pharm. Bachelor of Pharmacy Bachelor of Pharmacy (B.Pharm.) Pharmaceutical Chemistry 2

Question 1

Which functional group is responsible for the acidic character of aspirin?

Accepted Answer

Carboxylic acid group

Answer

Aspirin contains a carboxylic acid (-COOH) group that donates a proton, conferring its acidic character.

Question 2

What is the mechanism of action of sulfonamide antibacterial drugs?

Accepted Answer

Competitive inhibition of dihydropteroate synthase

Answer

Sulfonamides competitively inhibit dihydropteroate synthase, blocking bacterial folate synthesis.

Question 3

Which stereochemical descriptor system is used to assign absolute configuration to chiral centers in drug molecules?

Accepted Answer

R/S (Cahn-Ingold-Prelog) system

Answer

The R/S system (Cahn-Ingold-Prelog rules) assigns absolute configuration based on priority of substituents around a chiral center.

Question 4

What is the role of the ester bond in prodrug design?

Accepted Answer

To allow hydrolysis in vivo releasing the active drug

Answer

Ester prodrugs are hydrolyzed by esterases in vivo to release the pharmacologically active parent drug.

Question 5

Which reagent is commonly used in the Folin-Ciocalteu method to quantify phenolic compounds?

Accepted Answer

Folin-Ciocalteu reagent (phosphomolybdotungstic acid)

Answer

The Folin-Ciocalteu reagent (phosphomolybdotungstic acid) is reduced by phenols to produce a blue color measured spectrophotometrically.

B.Pharm. Bachelor of Pharmacy Practice Test