B.Pharm. Bachelor of Pharmacy Bachelor of Pharmacy (B.Pharm.) 4

Question 1

Which class of antibiotics works by inhibiting bacterial cell wall synthesis by blocking transpeptidation?

Accepted Answer

Beta-lactams

Answer

Beta-lactam antibiotics inhibit transpeptidases (penicillin-binding proteins), preventing cross-linking of peptidoglycan strands in the bacterial cell wall.

Question 2

A patient with renal impairment would require dose adjustment for which of the following drugs?

Accepted Answer

Gentamicin

Answer

Gentamicin is primarily eliminated unchanged by the kidneys, so renal impairment leads to drug accumulation and nephrotoxicity or ototoxicity if not dose-adjusted.

Question 3

Which excipient in tablet formulation is classified as a disintegrant?

Accepted Answer

Croscarmellose sodium

Answer

Croscarmellose sodium is a superdisintegrant that swells rapidly upon contact with water, breaking tablets apart to release the drug for dissolution.

Question 4

Selective serotonin reuptake inhibitors (SSRIs) treat depression by:

Accepted Answer

Preventing reuptake of serotonin into the presynaptic neuron

Answer

SSRIs block the serotonin transporter (SERT) on presynaptic neurons, preventing serotonin reuptake and increasing its availability in the synaptic cleft.

Question 5

Which process in drug metabolism typically converts lipophilic drugs to more polar metabolites for excretion?

Accepted Answer

Both Phase I and Phase II reactions

Answer

Phase I reactions (oxidation, reduction, hydrolysis) introduce functional groups, and Phase II reactions (conjugation) add large polar moieties, collectively increasing drug hydrophilicity for renal excretion.

B.Pharm. Bachelor of Pharmacy Practice Test

B.Pharm. Bachelor of Pharmacy Practice Test

B.Pharm. Bachelor of Pharmacy Bachelor of Pharmacy (B.Pharm.) 4