B.Pharm. Bachelor of Pharmacy Bachelor of Pharmacy (B.Pharm.) 3

Question 1

A drug with a high first-pass effect is best administered via which route to maximize bioavailability?

Accepted Answer

Sublingual

Answer

Sublingual administration bypasses the portal circulation, avoiding first-pass hepatic metabolism and achieving higher systemic bioavailability.

Question 2

What is the primary pharmacological action of HMG-CoA reductase inhibitors (statins)?

Accepted Answer

Inhibit the rate-limiting step of hepatic cholesterol synthesis

Answer

Statins competitively inhibit HMG-CoA reductase, the enzyme catalyzing the rate-limiting step in cholesterol biosynthesis in the liver.

Question 3

Which type of drug interaction occurs when one drug alters the absorption of another by chelation?

Accepted Answer

Pharmacokinetic interaction

Answer

Chelation-based absorption interactions are pharmacokinetic, where drugs like tetracyclines bind divalent cations (Ca2+, Mg2+) forming insoluble complexes that reduce absorption.

Question 4

The narrow therapeutic index of warfarin means that:

Accepted Answer

Small changes in dose can lead to toxicity or therapeutic failure

Answer

A narrow therapeutic index means the toxic dose is close to the therapeutic dose, requiring careful monitoring to maintain efficacy without causing bleeding.

Question 5

Which property of a solid dosage form is described by the angle of repose?

Accepted Answer

Powder flowability

Answer

The angle of repose measures the maximum angle a powder pile makes with a horizontal surface, indicating powder flowability for tablet and capsule manufacturing.

B.Pharm. Bachelor of Pharmacy Practice Test

B.Pharm. Bachelor of Pharmacy Practice Test

B.Pharm. Bachelor of Pharmacy Bachelor of Pharmacy (B.Pharm.) 3