B.Pharm. Bachelor of Pharmacy Bachelor of Pharmacy (B.Pharm.) 2

Question 1

Which enzyme is responsible for the conversion of arachidonic acid to prostaglandins?

Accepted Answer

Cyclooxygenase (COX)

Answer

Cyclooxygenase (COX) catalyzes the conversion of arachidonic acid to prostaglandin H2, the precursor to prostaglandins and thromboxanes.

Question 2

The Henderson-Hasselbalch equation is used in pharmacy primarily to:

Accepted Answer

Predict the ionization state of a drug at a given pH

Answer

The Henderson-Hasselbalch equation relates pH, pKa, and the ratio of ionized to unionized drug forms, predicting drug absorption and distribution.

Question 3

Which of the following is an example of a prodrug that requires hepatic activation?

Accepted Answer

Codeine

Answer

Codeine is a prodrug converted by CYP2D6 in the liver to morphine, which is the pharmacologically active metabolite responsible for analgesia.

Question 4

What is the primary mechanism of resistance to beta-lactam antibiotics in bacteria?

Accepted Answer

Beta-lactamase enzyme production

Answer

Beta-lactamase enzymes produced by resistant bacteria hydrolyze the beta-lactam ring, rendering the antibiotic inactive.

Question 5

In pharmacokinetics, zero-order kinetics means that drug elimination occurs:

Accepted Answer

At a constant rate regardless of drug concentration

Answer

Zero-order kinetics describes elimination at a fixed amount per unit time, independent of drug concentration, as seen with alcohol and phenytoin at high doses.

B.Pharm. Bachelor of Pharmacy Practice Test

B.Pharm. Bachelor of Pharmacy Practice Test

B.Pharm. Bachelor of Pharmacy Bachelor of Pharmacy (B.Pharm.) 2