B.Pharm. Bachelor of Pharmacy Pharmacology 2

Question 1

Which neurotransmitter is primarily depleted in Parkinson's disease, leading to motor deficits?

Accepted Answer

Dopamine

Answer

Parkinson's disease is characterized by degeneration of dopaminergic neurons in the substantia nigra, depleting dopamine and impairing motor control.

Question 2

Opioid analgesics primarily exert their effects by binding to which receptor type?

Accepted Answer

Mu opioid receptors

Answer

Mu (μ) opioid receptors are the primary targets mediating analgesia, euphoria, and respiratory depression caused by opioid drugs.

Question 3

Which drug is used as an antidote for acetaminophen (paracetamol) overdose?

Accepted Answer

N-acetylcysteine

Answer

N-acetylcysteine replenishes hepatic glutathione stores, neutralizing the toxic metabolite NAPQI formed during acetaminophen overdose.

Question 4

Beta-lactam antibiotics kill bacteria by inhibiting which process?

Accepted Answer

Cell wall synthesis

Answer

Beta-lactam antibiotics inhibit transpeptidase enzymes (penicillin-binding proteins), preventing cross-linking of peptidoglycan in bacterial cell walls.

Question 5

Which type of drug interaction occurs when one drug increases the plasma concentration of another by inhibiting its metabolism?

Accepted Answer

Enzyme inhibition

Answer

Enzyme inhibition reduces hepatic CYP450-mediated metabolism of a co-administered drug, raising its plasma levels and potentially causing toxicity.

B.Pharm. Bachelor of Pharmacy Practice Test

B.Pharm. Bachelor of Pharmacy Practice Test

B.Pharm. Bachelor of Pharmacy Pharmacology 2