ABPN Neuropharmacology and Psychopharmacology Flashcards

Which neurotransmitter system is the PRIMARY target of typical antipsychotic medications?

Answer: Dopamine (D2)

Typical antipsychotics primarily block dopamine D2 receptors, which accounts for both their antipsychotic efficacy and extrapyramidal side effects.

A patient on lithium develops tremor, polyuria, and polydipsia. What is the MOST appropriate next step?

Answer: Check serum lithium level

Checking the serum lithium level is essential to determine if symptoms reflect toxicity or are side effects at therapeutic levels.

Which antidepressant is MOST associated with serotonin syndrome when combined with an MAOI?

Answer: Fluoxetine

Fluoxetine, a potent SSRI with a long half-life, carries the highest risk of serotonin syndrome when combined with or shortly after an MAOI.

Tardive dyskinesia is MOST commonly caused by long-term use of which class of drugs?

Answer: Dopamine receptor antagonists

Tardive dyskinesia results from chronic blockade of dopamine receptors, causing receptor supersensitivity and abnormal involuntary movements.

Which anticonvulsant is considered FIRST-LINE for trigeminal neuralgia?

Answer: Carbamazepine

Carbamazepine is first-line for trigeminal neuralgia due to its efficacy in blocking sodium channels and reducing ectopic neuronal firing.

A patient taking clozapine develops fever, sore throat, and an absolute neutrophil count of 400/μL. What is the MOST appropriate action?

Answer: Immediately discontinue clozapine

Severe agranulocytosis (ANC < 500/μL) requires immediate discontinuation of clozapine to prevent life-threatening infection.