Pathology Flashcards

Which glomerular disease shows a 'wire-loop' appearance and is strongly associated with systemic lupus erythematosus?

Answer: Diffuse proliferative glomerulonephritis

Wire-loop lesions from subendothelial immune deposits characterize lupus diffuse proliferative GN.

Ferruginous bodies (asbestos bodies) in lung tissue indicate prior exposure to?

Answer: Asbestos

Iron-coated asbestos fibers form dumbbell-shaped ferruginous bodies.

Which tumor marker is most useful for monitoring hepatocellular carcinoma and certain germ-cell tumors?

Answer: Alpha-fetoprotein (AFP)

AFP is elevated in hepatocellular carcinoma and yolk-sac (endodermal sinus) tumors.

Signet-ring cells filled with mucin pushing the nucleus to the periphery are characteristic of which cancer?

Answer: Diffuse-type gastric adenocarcinoma

Signet-ring cells are typical of diffuse (linitis plastica) gastric carcinoma.

Caseating granulomas with central 'cheese-like' necrosis are most characteristic of?

Answer: Tuberculosis

Caseous (cheese-like) necrosis within granulomas is the hallmark of tuberculosis.

Which of the following is the most common type of skin cancer overall?

Answer: Basal cell carcinoma

Basal cell carcinoma is the most common cutaneous malignancy and rarely metastasizes.

A 'nutmeg liver' pattern on gross examination is most commonly caused by?

Answer: Chronic passive congestion

Chronic passive (right-heart failure) congestion produces the mottled nutmeg appearance.