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Hematopathology Flashcards

7 cards from real ABPATH practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. The CD30-positive, ALK-positive large cell lymphoma with t(2;5) is:

    Answer: Anaplastic large cell lymphoma

    ALK-positive ALCL carries t(2;5) NPM-ALK fusion and expresses CD30.

  2. A monoclonal IgM paraprotein with lymphoplasmacytic marrow infiltration and MYD88 L265P mutation defines:

    Answer: Waldenstrom macroglobulinemia

    Waldenstrom (lymphoplasmacytic lymphoma) produces IgM and carries the MYD88 L265P mutation.

  3. NPM1 mutation with a normal karyotype in AML is generally associated with:

    Answer: A favorable prognosis when FLT3-ITD is absent

    Isolated NPM1 mutation without FLT3-ITD confers a relatively favorable AML prognosis.

  4. Faggot cells (bundles of Auer rods) are most characteristic of:

    Answer: Acute promyelocytic leukemia

    Abnormal promyelocytes in APL contain bundles of Auer rods called faggot cells.

  5. A lymphoma of the stomach associated with Helicobacter pylori that may regress with antibiotics is:

    Answer: Extranodal marginal zone (MALT) lymphoma

    Gastric MALT lymphoma is driven by chronic H. pylori infection and can regress after eradication.

  6. Smudge cells on a peripheral smear are an artifact classically over-represented in:

    Answer: Chronic lymphocytic leukemia

    Fragile CLL lymphocytes rupture during smear preparation, producing smudge cells.

  7. Flow cytometry showing surface light-chain restriction confirms that a B-cell population is:

    Answer: Clonal (neoplastic)

    Restriction to a single kappa or lambda light chain indicates a clonal B-cell proliferation.