Practice Test GeeksAmerican Board of Pathology (ABPath) Practice Test
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Hematopathology Flashcards

7 cards from real ABPATH practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. Ring sideroblasts seen with Prussian blue staining are a feature of which category of disease?

    Answer: Myelodysplastic syndrome

    Ring sideroblasts reflect abnormal iron accumulation in mitochondria seen in certain MDS subtypes.

  2. Schistocytes on a peripheral smear together with thrombocytopenia most strongly suggest:

    Answer: Microangiopathic hemolytic anemia

    Fragmented red cells (schistocytes) with low platelets indicate a microangiopathic process such as TTP or DIC.

  3. Hypersegmented neutrophils and macro-ovalocytes on a smear are classic for:

    Answer: Megaloblastic anemia

    B12 or folate deficiency causes megaloblastic changes including hypersegmented neutrophils.

  4. A 'dry tap' on bone marrow aspiration with fibrosis and teardrop cells suggests:

    Answer: Primary myelofibrosis

    Marrow fibrosis in PMF yields a dry tap and dacrocytes (teardrop cells) on smear.

  5. Flow cytometry showing loss of CD55 and CD59 on blood cells is diagnostic of:

    Answer: Paroxysmal nocturnal hemoglobinuria

    PNH results from a PIGA mutation causing loss of GPI-anchored proteins CD55 and CD59.

  6. TdT positivity in a population of blasts is most typical of:

    Answer: Lymphoblastic leukemia/lymphoma

    Terminal deoxynucleotidyl transferase (TdT) marks immature lymphoblasts.

  7. A direct antiglobulin (Coombs) test positive with warm IgG antibodies and spherocytes indicates:

    Answer: Warm autoimmune hemolytic anemia

    Warm AIHA shows IgG-coated red cells, a positive DAT, and spherocytes from splenic macrophage nibbling.