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Hematopathology Flashcards

7 cards from real ABPATH practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. t(15;17) with PML-RARA fusion characterizes which subtype of acute myeloid leukemia?

    Answer: Acute promyelocytic leukemia

    APL is defined by t(15;17)/PML-RARA and responds to ATRA therapy.

  2. The t(8;14) translocation involving MYC is the classic cytogenetic finding in:

    Answer: Burkitt lymphoma

    Burkitt lymphoma harbors MYC translocation, most commonly t(8;14).

  3. A 'starry-sky' pattern on histology with a near-100% Ki-67 proliferation index suggests:

    Answer: Burkitt lymphoma

    Tingible-body macrophages create the starry-sky look, and Ki-67 approaches 100% in Burkitt lymphoma.

  4. Hairy cell leukemia is characteristically positive for which mutation?

    Answer: BRAF V600E

    BRAF V600E is present in essentially all hairy cell leukemia cases.

  5. TRAP (tartrate-resistant acid phosphatase) positivity and cytoplasmic projections point to which leukemia?

    Answer: Hairy cell leukemia

    Hairy cell leukemia classically shows TRAP positivity and hairy cytoplasmic projections.

  6. The t(14;18) translocation leading to BCL2 overexpression is most associated with:

    Answer: Follicular lymphoma

    t(14;18) juxtaposes BCL2 with the IgH locus, blocking apoptosis in follicular lymphoma.

  7. Cyclin D1 overexpression from t(11;14) is diagnostic of which lymphoma?

    Answer: Mantle cell lymphoma

    t(11;14) drives cyclin D1 (CCND1) overexpression, defining mantle cell lymphoma.