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Hematopathology Flashcards

7 cards from real ABPATH practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. Auer rods on a peripheral blood smear are most characteristic of which condition?

    Answer: Acute myeloid leukemia

    Auer rods are azurophilic cytoplasmic inclusions of fused primary granules seen in myeloblasts of AML.

  2. The t(9;22) BCR-ABL1 fusion is the defining genetic lesion of which chronic myeloproliferative neoplasm?

    Answer: Chronic myeloid leukemia

    The Philadelphia chromosome t(9;22) producing BCR-ABL1 defines CML.

  3. A CD5-positive, CD23-positive small B-cell lymphoma with smudge cells on smear is most consistent with:

    Answer: Chronic lymphocytic leukemia/small lymphocytic lymphoma

    CLL/SLL is CD5+/CD23+ and classically shows smudge cells on the peripheral smear.

  4. Reed-Sternberg cells are the diagnostic hallmark of which lymphoma?

    Answer: Classic Hodgkin lymphoma

    Binucleate Reed-Sternberg cells (CD15+/CD30+) define classic Hodgkin lymphoma.

  5. Which stain is used to demonstrate iron stores in bone marrow aspirate smears?

    Answer: Prussian blue (Perls)

    Prussian blue (Perls) reaction highlights hemosiderin iron in marrow.

  6. The JAK2 V617F mutation is most frequently associated with which myeloproliferative neoplasm?

    Answer: Polycythemia vera

    JAK2 V617F is present in nearly all cases of polycythemia vera.

  7. A serum protein electrophoresis showing a monoclonal M-spike with marrow plasmacytosis and lytic bone lesions indicates:

    Answer: Multiple myeloma

    M-spike with clonal plasma cells, lytic lesions, and end-organ damage defines multiple myeloma.