General Pathology Principles Flashcards

Healing by primary intention (first intention) is characteristic of:

Answer: A clean surgical incision with approximated edges

Primary intention healing occurs in clean wounds with closely apposed edges, requiring minimal granulation tissue.

The main cell responsible for collagen synthesis during wound repair is the:

Answer: Fibroblast

Fibroblasts produce the collagen and extracellular matrix that form the scar during repair.

Granulation tissue in a healing wound is composed of:

Answer: New capillaries and proliferating fibroblasts

Granulation tissue consists of new blood vessels (angiogenesis) and fibroblasts in a loose matrix.

A keloid represents which abnormality of wound healing?

Answer: Excessive collagen deposition beyond the wound margins

A keloid is an exuberant scar with excess collagen that extends beyond the original wound boundaries.

Which vitamin deficiency most directly impairs collagen synthesis and wound healing?

Answer: Vitamin C

Vitamin C is required for hydroxylation of proline and lysine in collagen synthesis, so its deficiency impairs healing.

Labile cells that continuously divide throughout life include:

Answer: Surface epithelium of the gut and skin

Labile cells such as gut and skin epithelium proliferate continuously to replace lost cells.

Regeneration, as opposed to repair by scarring, is possible only when:

Answer: The tissue framework and stem cells are intact

Regeneration restores original tissue only when the connective tissue scaffold is preserved and the cells can proliferate.