Practice Test GeeksAmerican Board of Pathology (ABPath) Practice Test
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Anatomic Pathology Flashcards

7 cards from real ABPATH practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

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  1. Which marker is most specific for melanoma among the following?

    Answer: HMB-45

    HMB-45 is a specific melanocytic marker used to confirm melanoma.

  2. A 'fried egg' appearance of cells with perinuclear halos is characteristic of:

    Answer: Oligodendroglioma

    Oligodendrogliomas show clear perinuclear halos, giving a fried-egg appearance.

  3. Which finding indicates high-grade dysplasia rather than invasive carcinoma in the colon?

    Answer: Cells confined above the basement membrane

    High-grade dysplasia lacks invasion beyond the basement membrane, unlike invasive carcinoma.

  4. Which stain is used to highlight fungal organisms and Pneumocystis in tissue?

    Answer: GMS (Grocott methenamine silver)

    GMS silver stain highlights fungi and Pneumocystis jirovecii as black organisms.

  5. Nuclear expression of TTF-1 supports a primary origin from the:

    Answer: Lung or thyroid

    TTF-1 is expressed in lung adenocarcinoma and thyroid tissue.

  6. Which of the following is a hallmark of malignancy rather than benign reactive change?

    Answer: Marked nuclear pleomorphism with atypical mitoses

    Atypical mitoses and marked pleomorphism favor malignancy.

  7. Estrogen receptor (ER) immunohistochemistry in breast cancer is primarily used to:

    Answer: Predict response to hormonal therapy

    ER status predicts benefit from endocrine (anti-estrogen) therapy.