Practice Test GeeksAmerican Board of Pathology (ABPath) Practice Test
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Gastrointestinal Pathology Flashcards

6 cards from real ABPATH practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

Read the first 6 Gastrointestinal Pathology flashcards as text

  1. Peutz-Jeghers syndrome is caused by germline mutations in which gene and features which type of polyp?

    Answer: STK11/LKB1; hamartomatous polyp

    Peutz-Jeghers syndrome is caused by STK11/LKB1 mutations and is characterized by hamartomatous polyps with arborizing smooth muscle cores throughout the GI tract.

  2. Collagenous colitis is distinguished from lymphocytic colitis by the presence of which histologic finding?

    Answer: Thickened subepithelial collagen band (>10 µm)

    Collagenous colitis features a thickened subepithelial collagen band >10 µm (normal <5 µm) with entrapment of capillaries, in addition to surface epithelial damage and increased IELs.

  3. The intestinal type of gastric adenocarcinoma is most strongly associated with which precursor condition?

    Answer: H. pylori-associated chronic atrophic gastritis with intestinal metaplasia

    The Correa cascade describes the progression: H. pylori gastritis → atrophic gastritis → intestinal metaplasia → dysplasia → intestinal-type gastric carcinoma.

  4. A signet-ring cell carcinoma of the stomach with diffuse infiltration and marked desmoplasia creating a 'leather bottle' appearance is termed:

    Answer: Scirrhous carcinoma (linitis plastica)

    Linitis plastica (scirrhous carcinoma) is a diffuse-type gastric adenocarcinoma characterized by signet-ring cells, desmoplastic stroma, and diffuse wall thickening without discrete mass.

  5. FAP (familial adenomatous polyposis) is caused by germline mutations in which gene, and what is the lifetime colorectal cancer risk without intervention?

    Answer: APC; nearly 100%

    FAP is caused by APC gene mutations (chromosome 5q21) and carries nearly 100% lifetime risk of colorectal cancer without prophylactic colectomy.

  6. Which histologic pattern of hepatocellular carcinoma is associated with the BEST prognosis?

    Answer: Fibrolamellar carcinoma

    Fibrolamellar carcinoma occurs in young patients without cirrhosis, has characteristic lamellar fibrous bands around tumor cells, and carries a significantly better prognosis than conventional HCC.