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Basic Science and Immunology Flashcards

7 cards from real ABD practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

Read the first 7 Basic Science and Immunology flashcards as text

  1. Which immune cell is the primary effector in a positive tuberculin (PPD) delayed-type hypersensitivity skin test?

    Answer: CD4+ T cell

    Type IV delayed hypersensitivity is mediated by sensitized CD4+ T cells recruiting macrophages.

  2. Allergic contact dermatitis to nickel is an example of which Gell and Coombs hypersensitivity type?

    Answer: Type IV

    Allergic contact dermatitis is a type IV, T-cell-mediated delayed hypersensitivity reaction.

  3. The dermis derives its tensile strength predominantly from which structural protein?

    Answer: Type I collagen

    Type I collagen is the most abundant dermal protein providing tensile strength.

  4. Ehlers-Danlos syndrome and cutis laxa illustrate defects in dermal matrix; which protein defect causes loss of elastic recoil in cutis laxa?

    Answer: Elastin

    Cutis laxa results from defective elastin/elastic fiber formation causing sagging inelastic skin.

  5. Which pattern-recognition receptors on keratinocytes sense microbial products to initiate innate cutaneous immunity?

    Answer: Toll-like receptors

    Toll-like receptors recognize conserved microbial patterns to trigger innate responses.

  6. Interferon-gamma released by Th1 cells primarily activates which cell to enhance intracellular pathogen killing?

    Answer: Macrophage

    IFN-gamma is the key macrophage-activating cytokine of the Th1 response.

  7. Merkel cells in the epidermis primarily function as:

    Answer: Mechanoreceptors for touch

    Merkel cells act as slow-adapting mechanoreceptors associated with sensory nerve endings.