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Basic Science and Immunology Flashcards

7 cards from real ABD practice questions. Tap to flip, then mark Knew It or Still Learning — missed cards come back until you master them.

Read the first 7 Basic Science and Immunology flashcards as text

  1. Which HLA allele is most strongly associated with an increased risk of carbamazepine-induced Stevens-Johnson syndrome in Han Chinese patients?

    Answer: HLA-B*1502

    HLA-B*1502 strongly predicts carbamazepine-induced SJS/TEN in Southeast Asian populations.

  2. The HLA-Cw6 allele shows the strongest genetic association with which dermatologic disease?

    Answer: Psoriasis

    HLA-Cw6 is the principal susceptibility allele for early-onset psoriasis.

  3. Which UV wavelength range is primarily responsible for direct DNA damage forming cyclobutane pyrimidine dimers?

    Answer: UVB (290-320 nm)

    UVB is directly absorbed by DNA, generating cyclobutane pyrimidine dimers.

  4. Xeroderma pigmentosum results from a defect in which DNA repair mechanism?

    Answer: Nucleotide excision repair

    XP is caused by defective nucleotide excision repair of UV-induced photoproducts.

  5. Regulatory T cells that suppress cutaneous autoimmunity are defined by expression of which transcription factor?

    Answer: FOXP3

    FOXP3 is the master transcription factor of regulatory T cells.

  6. Which cytokine, targeted by ustekinumab (with IL-12), is critical for Th17 differentiation in psoriasis?

    Answer: IL-23

    IL-23 maintains Th17 cells and is co-targeted by ustekinumab via the shared p40 subunit.

  7. Antimicrobial peptides such as cathelicidin (LL-37) are dysregulated in the pathogenesis of which condition?

    Answer: Rosacea

    Elevated cathelicidin and abnormal processing contribute to rosacea inflammation.