AKT Pharmacology and Prescribing

Question 1

A patient stabilized on warfarin begins taking ibuprofen regularly for joint pain. What is the primary prescribing concern?

Accepted Answer

Ibuprofen potentiates warfarin's anticoagulant effect, increasing bleeding risk

Answer

NSAIDs like ibuprofen inhibit platelet aggregation and can displace warfarin from protein-binding sites, synergistically increasing bleeding risk.

Question 2

Which of the following is the recommended first-line pharmacological treatment for Type 2 diabetes in a patient without contraindications?

Accepted Answer

Metformin

Answer

Metformin is universally recommended as first-line therapy for Type 2 diabetes due to its efficacy, safety profile, and low cost.

Question 3

A patient with a documented penicillin allergy needs antibiotic treatment. Which cephalosporin generation carries the greatest cross-reactivity risk?

Accepted Answer

First-generation cephalosporins

Answer

First-generation cephalosporins share the most structural similarity to penicillin via the R1 side chain, conferring the highest cross-reactivity risk.

Question 4

What is the maximum recommended daily dose of acetaminophen (paracetamol) for a healthy adult?

Accepted Answer

4,000 mg

Answer

The maximum safe daily dose of acetaminophen for healthy adults is 4,000 mg (4 g), though 3,000 mg/day is recommended for chronic use or in patients at hepatic risk.

Question 5

Which class of antihypertensive is contraindicated during pregnancy due to risk of fetal renal dysgenesis?

Accepted Answer

ACE inhibitors

Answer

ACE inhibitors are teratogenic in the second and third trimesters, causing fetal renal tubular dysgenesis, oligohydramnios, and neonatal anuria.

AKT - Applied Knowledge Test Practice Test

AKT - Applied Knowledge Test Practice Test

AKT Pharmacology and Prescribing