AKT Pharmacology and Prescribing

Question 1

A patient stabilized on warfarin begins taking ibuprofen regularly for joint pain. What is the primary prescribing concern?

Accepted Answer

Ibuprofen potentiates warfarin's anticoagulant effect, increasing bleeding risk

Answer

Ibuprofen reduces warfarin absorption

Answer

Ibuprofen causes warfarin metabolism to increase

Answer

Ibuprofen displaces warfarin from plasma proteins, reducing its effect

Question 2

Which of the following is the recommended first-line pharmacological treatment for Type 2 diabetes in a patient without contraindications?

Accepted Answer

Metformin

Answer

Glipizide

Answer

Insulin glargine

Answer

Sitagliptin

Question 3

A patient with a documented penicillin allergy needs antibiotic treatment. Which cephalosporin generation carries the greatest cross-reactivity risk?

Accepted Answer

First-generation cephalosporins

Answer

Fourth-generation cephalosporins

Answer

Third-generation cephalosporins

Answer

Second-generation cephalosporins

Question 4

What is the maximum recommended daily dose of acetaminophen (paracetamol) for a healthy adult?

Accepted Answer

4,000 mg

Answer

2,000 mg

Answer

3,000 mg

Answer

6,000 mg

Question 5

Which class of antihypertensive is contraindicated during pregnancy due to risk of fetal renal dysgenesis?

Accepted Answer

ACE inhibitors

Answer

Calcium channel blockers

Answer

Beta-blockers

Answer

Methyldopa

Question 6

A patient on long-term lithium therapy presents with polydipsia, polyuria, and dilute urine. What is the most likely explanation?

Accepted Answer

Lithium-induced nephrogenic diabetes insipidus

Answer

Lithium-induced hyperglycemia

Answer

Lithium-induced central diabetes insipidus

Answer

Lithium toxicity causing SIADH

Question 7

Which of the following drugs requires routine therapeutic drug monitoring (TDM) of serum levels in clinical practice?

Accepted Answer

Digoxin

Answer

Amoxicillin

Answer

Lisinopril

Answer

Atorvastatin