A patient stabilized on methadone maintenance wants to transition to buprenorphine. What is the primary clinical concern during this transition?
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A
Risk of serotonin syndrome due to drug-drug interactions
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B
Risk of precipitated withdrawal because buprenorphine is a partial agonist displacing methadone
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C
Requirement for a 30-day washout period before buprenorphine can be started
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D
Buprenorphine is contraindicated in patients who have ever used methadone