A patient with opioid use disorder declines buprenorphine and methadone but agrees to naltrexone. What is the most important pre-treatment step?
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A
Complete at least 14 days of medically supervised abstinence from all substances
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B
Confirm opioid-free status for 7–10 days (short-acting) or 10–14 days (long-acting) before initiating naltrexone
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C
Perform a urine drug screen only for fentanyl
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D
Initiate naltrexone while still on low-dose buprenorphine