ABD Inflammatory Dermatoses 4

Question 1

Atopic dermatitis in infancy classically involves which body regions?

Accepted Answer

Cheeks and extensor surfaces

Answer

Infantile atopic dermatitis favors the face (cheeks) and extensor surfaces, shifting to flexures later in childhood.

Question 2

A loss-of-function mutation in which gene is a major genetic risk factor for atopic dermatitis?

Accepted Answer

Filaggrin (FLG)

Answer

Filaggrin mutations impair the epidermal barrier and strongly predispose to atopic dermatitis and ichthyosis vulgaris.

Question 3

The 'atopic triad' associated with atopic dermatitis includes asthma, allergic rhinitis, and what?

Accepted Answer

Atopic dermatitis (eczema) itself

Answer

The atopic triad comprises atopic dermatitis, allergic rhinitis, and asthma.

Question 4

Eczema herpeticum, a dermatologic emergency in atopic patients, is caused by disseminated infection with which virus?

Accepted Answer

Herpes simplex virus

Answer

Eczema herpeticum is widespread HSV infection over eczematous skin, requiring prompt antiviral therapy.

Question 5

Which topical calcineurin inhibitor is used as a steroid-sparing agent for atopic dermatitis, especially on the face?

Accepted Answer

Tacrolimus

Answer

Tacrolimus (and pimecrolimus) are calcineurin inhibitors useful for sensitive areas without steroid atrophy risk.

American Board of Dermatology (ABD) Practice Test