VTNE Veterinary Pharmacology Questions and Answers

Question 1

A veterinarian prescribes phenobarbital for a 5-year-old dog diagnosed with idiopathic epilepsy. What is the primary mechanism of action for this drug?

Accepted Answer

Enhancing the effect of the inhibitory neurotransmitter GABA

Answer

Blocking voltage-gated sodium channels

Answer

Antagonizing glutamate receptors

Answer

Inhibiting the reuptake of serotonin and norepinephrine

Question 2

A 12-kg dog is prescribed carprofen for osteoarthritis at a dose of 2.2 mg/kg BID. The clinic stocks 50 mg scored tablets. How many tablets should be dispensed for a 10-day supply?

Accepted Answer

10 tablets

Answer

5 tablets

Answer

20 tablets

Answer

15 tablets

Question 3

Which of the following is a common, and potentially serious, class-wide side effect of non-steroidal anti-inflammatory drugs (NSAIDs) in dogs?

Accepted Answer

Gastrointestinal ulceration

Answer

Polyuria and polydipsia

Answer

Iatrogenic hyperadrenocorticism

Answer

Alopecia

Question 4

A Collie presents with severe neurological signs, including ataxia and seizures, after receiving a high dose of ivermectin for mange treatment. This adverse reaction is most likely due to a mutation in which gene?

Accepted Answer

MDR1 (ABCB1)

Answer

CYP2D15

Answer

NK-1

Answer

COX-2

Question 5

Maropitant (Cerenia®) is a widely used antiemetic in veterinary medicine. It provides broad-spectrum anti-vomiting effects by acting as a:

Accepted Answer

Neurokinin-1 (NK-1) receptor antagonist

Answer

Dopamine D2 receptor antagonist

Answer

Serotonin 5-HT3 receptor antagonist

Answer

Histamine H1 receptor antagonist

Question 6

A veterinarian prescribes Clomicalm® (clomipramine hydrochloride) for a dog with separation anxiety. Which of the following is a potential side effect that the owner should be counseled about?

Accepted Answer

Lethargy or sedation

Answer

Increased aggression

Answer

Hyperactivity

Answer

Polyphagia