A pharmaceutical trial shows Drug X reduces headache duration by 30% compared to placebo, but only in patients under 50. The study has 200 participants, 150 of whom are under 50. Which limitation is most significant?
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A
The sample size is too small overall
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B
The age distribution limits generalizability to older patients
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C
The placebo effect was not controlled
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D
The drug should have been tested on more conditions