SPEX SPEX Pharmacology 2

Question 1

Which medication requires routine monitoring of serum drug levels due to its narrow therapeutic index?

Accepted Answer

Lithium

Answer

Amoxicillin

Answer

Metformin

Answer

Atorvastatin

Question 2

A patient develops 'red man syndrome' during IV infusion. Which drug is responsible?

Accepted Answer

Vancomycin

Answer

Penicillin G

Answer

Ceftriaxone

Answer

Azithromycin

Question 3

Which antihypertensive is contraindicated in bilateral renal artery stenosis?

Accepted Answer

ACE inhibitors

Answer

Amlodipine

Answer

Hydrochlorothiazide

Answer

Beta-blockers

Question 4

Which cytochrome P450 enzyme is primarily responsible for metabolizing warfarin and many other drugs?

Accepted Answer

CYP2C9

Answer

CYP1A2

Answer

CYP3A4

Answer

CYP2D6

Question 5

What is the mechanism of action of statins in lowering LDL cholesterol?

Accepted Answer

Blocking HMG-CoA reductase

Answer

Inhibiting bile acid reabsorption

Answer

Activating LDL receptors directly

Answer

Inhibiting cholesterol absorption in the gut

Question 6

A patient taking rifampin for tuberculosis has reduced efficacy of their oral contraceptive. Why?

Accepted Answer

Rifampin induces CYP3A4

Answer

Rifampin inhibits CYP3A4

Answer

Rifampin blocks estrogen receptors

Answer

Rifampin impairs GI absorption