RP Pharmacology Fundamentals 2

Question 1

A client on an SSRI reports onset of restlessness, agitation, and muscle twitching after their physician added tramadol. Which condition is most likely occurring?

Accepted Answer

Serotonin syndrome

Answer

Combining SSRIs with tramadol (which inhibits serotonin reuptake) can precipitate serotonin syndrome, characterized by agitation, autonomic instability, and neuromuscular abnormalities.

Question 2

Which class of medications works by blocking dopamine D2 receptors and is most associated with tardive dyskinesia with long-term use?

Accepted Answer

First-generation antipsychotics

Answer

First-generation (typical) antipsychotics block D2 receptors and are strongly associated with tardive dyskinesia, an involuntary movement disorder, after prolonged use.

Question 3

A client taking lithium develops coarse tremor, polyuria, and confusion. Serum lithium is 2.4 mEq/L. What is the priority clinical concern?

Accepted Answer

Lithium toxicity

Answer

Lithium levels above 1.5 mEq/L indicate toxicity; levels above 2.0 mEq/L are severe and require immediate medical intervention.

Question 4

Which pharmacokinetic process describes the conversion of an active drug into inactive metabolites, primarily occurring in the liver?

Accepted Answer

Biotransformation (metabolism)

Answer

Biotransformation (metabolism) converts drugs into metabolites, mostly via hepatic CYP450 enzymes, often rendering them inactive for excretion.

Question 5

A client is prescribed a medication with a half-life of 24 hours. Approximately how long will it take to reach steady-state plasma concentration?

Accepted Answer

4–5 days

Answer

Steady state is typically reached after approximately 4–5 half-lives, so a drug with a 24-hour half-life reaches steady state in about 4–5 days.

(RP) Registered Psychotherapist Certification Practice Test

(RP) Registered Psychotherapist Certification Practice Test

RP Pharmacology Fundamentals 2