PTCE Drug Classifications 3

Question 1

Which drug class works by blocking the conversion of angiotensin I to angiotensin II?

Accepted Answer

ACE inhibitors

Answer

ACE inhibitors block angiotensin-converting enzyme, preventing the formation of angiotensin II from angiotensin I.

Question 2

A medication labeled as a 'first-generation antihistamine' would be expected to cause which side effect not seen with second-generation agents?

Accepted Answer

Sedation

Answer

First-generation antihistamines (e.g., diphenhydramine) cross the blood-brain barrier causing sedation, unlike second-generation agents like loratadine.

Question 3

Which class of drugs is used as mood stabilizers and requires monitoring of serum drug levels due to a narrow therapeutic index?

Accepted Answer

Lithium salts

Answer

Lithium has a narrow therapeutic index (0.6–1.2 mEq/L) requiring regular serum level monitoring to avoid toxicity.

Question 4

Fluoroquinolones exert their antibacterial effect by inhibiting which bacterial enzyme?

Accepted Answer

DNA gyrase/topoisomerase II

Answer

Fluoroquinolones (e.g., ciprofloxacin) inhibit bacterial DNA gyrase and topoisomerase IV, preventing DNA replication.

Question 5

Which drug class is used to prevent rejection after organ transplantation by suppressing T-cell activation?

Accepted Answer

Calcineurin inhibitors

Answer

Calcineurin inhibitors (cyclosporine, tacrolimus) block calcineurin, preventing IL-2 production and T-cell activation.

(PTCE) Pharmacy Technician Certification Exam Practice Test

(PTCE) Pharmacy Technician Certification Exam Practice Test

PTCE Drug Classifications 3