PTCE Compounding 4

Question 1

The term 'tonicity' in compounded ophthalmic solutions refers to:

Accepted Answer

Osmotic pressure relative to blood or tears

Answer

The viscosity of the solution

Answer

The pH of the preparation

Answer

The sterility level of the product

Question 2

Which of the following is an example of a compounded preparation that requires protection from light during storage?

Accepted Answer

Nitroglycerin transdermal gel

Answer

Calcium gluconate IV solution

Answer

Normal saline irrigation

Answer

Potassium chloride oral liquid

Question 3

When calculating the amount of active drug needed for a compounded preparation, a technician uses the formula: quantity = (strength desired × volume desired) / stock strength. This is an application of which concept?

Accepted Answer

Dilution equation (C1V1 = C2V2)

Answer

Alligation

Answer

Geometric dilution

Answer

Weight-in-volume calculation

Question 4

A pharmacy must comply with USP <800> when handling which category of compounding ingredients?

Accepted Answer

Hazardous drugs (HDs)

Answer

Controlled substances

Answer

Non-sterile preparations only

Answer

OTC ingredients

Question 5

Which equipment is used to measure small volumes of liquid (< 1 mL) accurately in a compounding pharmacy?

Accepted Answer

Calibrated oral syringe or micropipette

Answer

Graduated cylinder

Answer

Beaker

Answer

Conical flask

Question 6

What does 'geometric dilution' ensure when incorporating a small amount of a potent drug powder into a larger base?

Accepted Answer

Uniform distribution of the drug throughout the preparation

Answer

Faster dissolution of the drug

Answer

Lower particle size of the drug

Answer

Sterilization of the final product

Question 7

A technician is compounding a preparation requiring a pH of 4.5. Which ingredient would be MOST appropriate as a buffer?

Accepted Answer

Sodium acetate / acetic acid buffer system

Answer

Sodium bicarbonate

Answer

Sodium hydroxide alone

Answer

Distilled water